Mechanism of acute kidney injury′s causing other distant organs dysfunction

Acute kidney injury (AKI) is associated with a higher mortality. Some studies have shown that the high mortality of AKI patients is closely related with dysfunction of other organs such as lungs, heart, liver, and nervous system. At present, growing evidence indicates that AKI induces other organs dysfunction by systemic inflammation. Identified pathways include: renal local inflammation; blood uric acid increasing through activation of purine...