Chemical Proteomic Profiling of the Interacting Proteins of Isoprenoid Pyrophosphates
Abstract
Isoprenoid pyrophosphates are involved in protein prenylation and assume regulatory roles in cells; however, little is known about the cellular proteins that can interact with isoprenoid pyrophosphates. Here, we devised a chemical proteomic strategy, capitalizing on the use of a desthiobiotin-geranyl pyrophosphate (GPP) acyl phosphate probe for the enrichment and subsequent identification of GPP-binding proteins using liquid...
Paper Details
Title
Chemical Proteomic Profiling of the Interacting Proteins of Isoprenoid Pyrophosphates
Published Date
May 18, 2020
Journal
Volume
92
Issue
12
Pages
8031 - 8036
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