Test-statistic inflation in methylome-wide association studies
Abstract
Recent years have seen a surge of methylome-wide association studies (MWAS). We observed that many of these studies suffer from test statistic inflation that is most likely caused by commonly used quality control (QC) pipelines not going far enough to remove technical artefacts. To support this claim, we reanalysed GEO datasets with an improved QC pipeline that reduced test-statistic inflation parameter lambda from the original mean/median of...
Paper Details
Title
Test-statistic inflation in methylome-wide association studies
Published Date
May 19, 2020
Journal
Volume
15
Issue
11
Pages
1163 - 1166
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