Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype

Volume: 41, Issue: 26, Pages: 2442 - 2453
Published: May 19, 2020
Abstract
Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two remains elusive. Methods and results Two independent case–control studies were conducted involving 307 AAD patients and 399 healthy...
Paper Details
Title
Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype
Published Date
May 19, 2020
Volume
41
Issue
26
Pages
2442 - 2453
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