Direct observation of a coil-to-helix contraction triggered by vinculin binding to talin

Volume: 6, Issue: 21
Published: May 22, 2020
Abstract
Vinculin binds unfolded talin domains in focal adhesions, which recruits actin filaments to reinforce the mechanical coupling of this organelle. However, it remains unknown how this interaction is regulated and its impact on the force transmission properties of this mechanotransduction pathway. Here, we use magnetic tweezers to measure the interaction between vinculin head and the talin R3 domain under physiological forces. For the first time,...
Paper Details
Title
Direct observation of a coil-to-helix contraction triggered by vinculin binding to talin
Published Date
May 22, 2020
Volume
6
Issue
21
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