Hypoxia Increases β-Cell Death by Activating Pancreatic Stellate Cells within the Islet
Abstract
Background Hypoxia can occur in pancreatic islets in type 2 diabetes mellitus. Pancreatic stellate cells (PSCs) are activated during hypoxia. Here we aimed to investigate whether PSCs within the islet are also activated in hypoxia, causing β-cell injury. Methods Islet and primary PSCs were isolated from Sprague Dawley rats, and cultured in normoxia (21% O2) or hypoxia (1% O2). The expression of α-smooth muscle actin (α-SMA), as measured by...
Paper Details
Title
Hypoxia Increases β-Cell Death by Activating Pancreatic Stellate Cells within the Islet
Published Date
Dec 31, 2020
Volume
44
Issue
6
Pages
919 - 927
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