MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
Abstract
The EphA2 receptor is found at high levels in tumors and low levels in normal tissue and high EphA2 expression in biopsies is a predictor of poor outcome in patients. Drug discovery groups have therefore sought to develop EphA2-based therapies using small molecule, peptide, and nanoparticle-based approaches (1–3). However, until now only EphA2-targeting antibody–drug conjugates (ADC) have entered clinical development. For example, MEDI-547 is an...
Paper Details
Title
MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
Published Date
Jul 1, 2020
Volume
19
Issue
7
Pages
1385 - 1394
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