MMAE Delivery Using the Bicycle Toxin Conjugate BT5528

Volume: 19, Issue: 7, Pages: 1385 - 1394
Published: Jul 1, 2020
Abstract
The EphA2 receptor is found at high levels in tumors and low levels in normal tissue and high EphA2 expression in biopsies is a predictor of poor outcome in patients. Drug discovery groups have therefore sought to develop EphA2-based therapies using small molecule, peptide, and nanoparticle-based approaches (1–3). However, until now only EphA2-targeting antibody–drug conjugates (ADC) have entered clinical development. For example, MEDI-547 is an...
Paper Details
Title
MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
Published Date
Jul 1, 2020
Volume
19
Issue
7
Pages
1385 - 1394
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