Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer

Volume: 22, Issue: 1
Published: May 1, 2020
Abstract
Background Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors . We previously reported that phospho-Ser134-GR (pS134-GR) species are elevated in triple-negative breast cancer (TNBC) and cooperate with hypoxia-inducible factors, providing a novel avenue for activation of GR in response to local or cellular stress. Methods We probed GR regulation by factors (cytokines, growth factors)...
Paper Details
Title
Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer
Published Date
May 1, 2020
Volume
22
Issue
1
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