The metalloproteinase ADAM10 requires its activity to sustain surface expression

Volume: 78, Issue: 2, Pages: 715 - 732
Published: May 5, 2020
Abstract
The metalloproteinase ADAM10 critically contributes to development, inflammation, and cancer and can be controlled by endogenous or synthetic inhibitors. Here, we demonstrate for the first time that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces removal of the protease from the cell surface and the whole cell. This process is temperature dependent, restricted to mature ADAM10, and associated...
Paper Details
Title
The metalloproteinase ADAM10 requires its activity to sustain surface expression
Published Date
May 5, 2020
Volume
78
Issue
2
Pages
715 - 732
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