IDDF2019-ABS-0203 SCNN1B Functions as a tumor suppressor in colorectal cancer by inhibiting RAS-RAF-MEK-ERK pathway

Background

The incidence of colorectal cancer (CRC) is rapidly rising worldwide. Understanding the molecular mechanism underlying CRC pathogenesis is critical to uncover novel drug targets and diagnostics for this disease. Our preliminary work identified SCNN1B as an outlier down-regulated in CRC. SCNN1B mRNA and protein expression were down-regulated in primary CRC and CRC cell lines, suggesting that it might function as a tumor...