Synthesis and evaluation of 11C- and 18F-labeled SOAT1 inhibitors as macrophage foam cell imaging agents
Abstract
PD-132301, an inhibitor of sterol O-acyltransferase 1 (SOAT1; also known as acyl-coenzyme A:cholesterol acyltransferase-1, ACAT1), is under clinical investigation for numerous adrenal disorders. Radiolabeled SOAT1 inhibitors could support drug discovery and help diagnose SOAT1-related disorders, such as atherosclerosis. We synthesized two radiolabeled SOAT1 inhibitors, [11C]PD-132301 and fluorine analogue [18F]1. Rat biodistribution studies were...
Paper Details
Title
Synthesis and evaluation of 11C- and 18F-labeled SOAT1 inhibitors as macrophage foam cell imaging agents
Published Date
Apr 30, 2020
Volume
11
Issue
6
Pages
1299 - 1304
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