Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm
Abstract
Angiotensin II (AngII) is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells (VSMCs), exposure to AngII induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in AngII-associated AAA remains unexplored. Here, we tested the hypothesis that mitochondrial fission is involved in the development of...
Paper Details
Title
Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm
Published Date
May 8, 2020
Journal
Volume
117
Issue
3
Pages
971 - 982
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