Controlled transdermal release of antioxidant ferulate by a porous Sc(III) MOF

Published on Jun 26, 2020in iScience4.447
· DOI :10.1016/J.ISCI.2020.101156
Génesis Osorio-Toribio1
Estimated H-index: 1
(UNAM: National Autonomous University of Mexico),
Miriam de J. Velásquez-Hernández5
Estimated H-index: 5
(Graz University of Technology)
+ 11 AuthorsIlich A. Ibarra25
Estimated H-index: 25
(UNAM: National Autonomous University of Mexico)
Sources
Abstract
Summary The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells) and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way towards the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).
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