An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non–small-cell lung cancer

BackgroundDissemination of non–small-cell lung cancer (NSCLC) in the central nervous system is a frequent and challenging clinical problem. Systemic or local therapies rarely prolong survival and have modest activity regarding local control. Alterations in gene expression in brain metastasis versus primary tumour may increase aggressiveness and impair therapeutic efforts.MethodsWe identified 25 patients with surgically removed NSCLC brain...