ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction

ZO-1 (Zona occludens 1), encoded by the tight junction protein 1 (TJP1) gene, is a regulator of paracellular permeability in epithelia and endothelia. ZO-1 interacts with the actin cytoskeleton, gap, and adherens junction proteins and localizes to intercalated discs in cardiomyocytes. However, the contribution of ZO-1 to cardiac physiology remains poorly defined.We aim to determine the role of ZO-1 in cardiac function.Inducible...