Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity
Abstract
Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through a low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the insulin...
Paper Details
Title
Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity
Published Date
Apr 24, 2020
Journal
Volume
11
Issue
1
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