X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice.

Published on Apr 29, 2020in Journal of Radiation Research1.95
· DOI :10.1093/JRR/RRAA022
Takahiro Kataoka16
Estimated H-index: 16
(RMIT: RMIT University),
Hina Shuto1
Estimated H-index: 1
(RMIT: RMIT University)
+ 7 AuthorsKiyonori Yamaoka28
Estimated H-index: 28
(RMIT: RMIT University)
Sources
Abstract
The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4 h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.
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