Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex
Abstract
Misfolded luminal endoplasmic reticulum (ER) proteins undergo ER-associated degradation (ERAD-L): They are retrotranslocated into the cytosol, polyubiquitinated, and degraded by the proteasome. ERAD-L is mediated by the Hrd1 complex (composed of Hrd1, Hrd3, Der1, Usa1, and Yos9), but the mechanism of retrotranslocation remains mysterious. Here, we report a structure of the active Hrd1 complex, as determined by cryo-electron microscopy analysis...
Paper Details
Title
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex
Published Date
Apr 24, 2020
Journal
Volume
368
Issue
6489
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