Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response
Abstract
Substance P (SP), an injury-inducible messenger that mobilizes bone marrow stem cells and modulates the immune response, has been suggested as a novel target for therapeutic agents. We evaluated the role of SP as an immune cell modulator during the progression of renal ischemic/reperfusion injury (IRI). Unilateral IRI induced the transient expression of endogenous SP and the infiltration of CCR7+ M1 macrophages in injured kidneys. However, SP...
Paper Details
Title
Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response
Published Date
Apr 23, 2020
Journal
Volume
11
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