Silybin as a potent inhibitor of a-synuclein aggregation and associated cytotoxicity against neuroblastoma cells induced by zinc oxide nanoparticles

a-synuclein (a-syn) amyloid fibrils, the leading neurotoxic types, are predominately formed through interaction with nanoparticles (NPs). However, some natural compounds like silybin can reduce the formation of NPs-induced amyloid fibrils and related cytotoxicity. Herein, we assayed the ZnO-induced a-syn amyloid fibril formation and underlying cytotoxicity in the absence and presence of silybin using a wide range of multispectroscopic (ThT...