Two pairs of diastereoisomeric isoflavone glucosides from the roots of Pueraria lobata

Phytochemical investigation of the roots of Pueraria lobata led to the isolation of two pairs of new isoflavone glucosides, 3′-hydroxyneopuerarin A/B (1–2) and 3′-methoxyneopuerarin A/B (3–4). A pair of known compounds (5–6), which possess a very similar structure, were obtained together. Their structures were elucidated on the basis of spectroscopic data interpretation. Compounds 3–6 dose-dependently blocked the production of TNF-α and IL-6 in...