Gene-Specific Control of tRNA Expression by RNA Polymerase II
Abstract
Increasing evidence suggests that tRNA levels are dynamically and specifically regulated in response to internal and external cues to modulate the cellular translational program. However, the molecular players and the mechanisms regulating the gene-specific expression of tRNAs are still unknown. Using an inducible auxin-degron system to rapidly deplete RPB1 (the largest subunit of RNA Pol II) in living cells, we identified Pol II as a direct...
Paper Details
Title
Gene-Specific Control of tRNA Expression by RNA Polymerase II
Published Date
May 1, 2020
Journal
Volume
78
Issue
4
Pages
765 - 778.e7
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History