Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2

Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that, under flow, von Willebrand factor/glycoprotein Ibα-dependent platelet ‘priming’ induces integrin α IIb β 3 activation that, in turn, mediates neutrophil and T-cell binding. Binding of platelet α IIb β 3 to SLC44A2 on neutrophils leads to...