Pyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer
Abstract
Advances in bioconjugation, the ability to link biomolecules to each other, small molecules, surfaces, and more, can spur the development of advanced materials and therapeutics. We have discovered that pyrocinchonimide, the dimethylated analogue of maleimide, undergoes a surprising transformation with biomolecules. The reaction targets amines and involves an imide transfer, which has not been previously reported for bioconjugation purposes....
Paper Details
Title
Pyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer
Published Date
Apr 17, 2020
Journal
Volume
31
Issue
5
Pages
1449 - 1462
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