The anti‐fibrotic actions of relaxin are mediated through AT₂R‐associated protein phosphatases via RXFP1‐AT₂R functional crosstalk in human cardiac myofibroblasts

Fibrosis is a hallmark of several cardiovascular diseases. The relaxin family peptide receptor 1 (RXFP1) agonist, relaxin, has rapidly occurring anti-fibrotic actions which are mediated through RXFP1 and angiotensin II receptor crosstalk on renal and cardiac myofibroblasts. Here, we investigated whether this would allow relaxin to indirectly activate angiotensin II type 2 receptor (AT2R)-specific signal transduction in primary human cardiac...