The network structure of core depressive symptom-domains in major depressive disorder following antidepressant treatment: a randomized clinical trial

Network analysis (NA) conceptualizes psychiatric disorders as complex dynamic systems of mutually interacting symptoms. Major depressive disorder (MDD) is a heterogeneous clinical condition, and very few studies to date have assessed putative changes in its psychopathological network structure in response to antidepressant (AD) treatment.In this randomized trial with adult depressed outpatients (n = 151), we estimated Gaussian graphical models...