Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
Abstract
Collagen-producing cells maintain the complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all collagen-producing cells in normal and fibrotic lungs. We characterize multiple collagen-producing subpopulations with distinct anatomical localizations in different compartments of murine lungs. One subpopulation, characterized by expression of Cthrc1 (collagen...
Paper Details
Title
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
Published Date
Apr 21, 2020
Journal
Volume
11
Issue
1
Pages
1920 - 1920
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History