Progress on ocular siRNA gene-silencing therapy and drug delivery systems.

Volume: 35, Issue: 1, Pages: 4 - 24
Published: Feb 1, 2021
Abstract
Age-related macular degeneration (AMD) and glaucoma are global ocular diseases with high blindness rate. RNA interference (RNAi) is being increasingly used in the treatment of these disorders with siRNA drugs, bevasiranib, AGN211745 and PF-04523655 for AMD, and SYL040012 and QPI-1007 for glaucoma. Administration routes and vectors of gene drugs affect their therapeutic effect. Compared with the non-viral vectors, viral vectors have limited...
Paper Details
Title
Progress on ocular siRNA gene-silencing therapy and drug delivery systems.
Published Date
Feb 1, 2021
Volume
35
Issue
1
Pages
4 - 24
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