Integration of GPCR‐induced endothelial cytoprotection signaling by β‐arrestin‐2

Vascular dysfunction is a hallmark of inflammation and results in endothelial barrier disruption, vascular leakage and apoptosis. G protein‐coupled receptors (GPCRs) are highly druggable and mediate inflammatory responses associated with endothelial dysfunction. Specifically, two GPCRs, protease‐activated receptor‐1 (PAR1) and sphingosine‐1‐phosphate receptor‐1 (S1PR1) promote endothelial cytoprotection including barrier protection, Akt‐mediated...