Structure–Activity Relationship of SPOP Inhibitors against Kidney Cancer
Abstract
Speckle-type POZ protein (SPOP) is overexpressed in the nucleus and misallocated in the cytoplasm in almost all the clear-cell renal cell carcinomas (ccRCCs), which leads to kidney tumorigenesis. Previously, we elucidated that the oncogenic SPOP-signaling pathway in ccRCC could be suppressed by 6b that inhibits SPOP-mediated protein interactions. Herein, we have established a structure–activity relationship for 6b analogues as SPOP inhibitors....
Paper Details
Title
Structure–Activity Relationship of SPOP Inhibitors against Kidney Cancer
Published Date
Apr 16, 2020
Volume
63
Issue
9
Pages
4849 - 4866
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