Novel application of capillary electrophoresis with a liposome coated capillary for prediction of blood-brain barrier permeability
Abstract
Profiling blood-brain barrier permeability of bioactive molecule is an important issue in early drug development, being a part of the optimization process of a compound's physicochemical properties, and hence pharmacokinetic profile. The study aimed to develop and optimize a new in vitro method for assessment of the compound's brain penetration. The tool is proposed as an alternative to the PAMPA-BBB (Parallel Artificial Membrane Permeability...
Paper Details
Title
Novel application of capillary electrophoresis with a liposome coated capillary for prediction of blood-brain barrier permeability
Published Date
Sep 1, 2020
Journal
Volume
217
Pages
121023 - 121023
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History