Acylphloroglucinols-based meroterpenoid enantiomers with antiviral activities from Dryopteris crassirhizoma

The rhizome of Dryopteris crassirhizoma Nakai is an important traditional Chinese medicine listed in Chinese Pharmacopoeia for the treatment of parasitic infestation and viral diseases. In this work, ten enantiomeric pairs of new acylphloroglucinol meroterpenoids, (±)-dryocrassoids A − J [(±)-1−10], along with six known acylphloroglucinols (11−16) were isolated from the rhizomes of D. crassirhizoma. Notably, these new enantiomers were the first...