Electro-Osmotic Vortices Promote the Capture of Folded Proteins by PlyAB Nanopores
Abstract
Biological nanopores are emerging as powerful tools for single-molecule analysis and sequencing. Here, we engineered the two-component pleurotolysin (PlyAB) toxin to assemble into 7.2 × 10.5 nm cylindrical nanopores with a low level of electrical noise in lipid bilayers, and we addressed the nanofluidic properties of the nanopore by continuum simulations. Surprisingly, proteins such as human albumin (66.5 kDa) and human transferrin (76–81 kDa)...
Paper Details
Title
Electro-Osmotic Vortices Promote the Capture of Folded Proteins by PlyAB Nanopores
Published Date
Apr 9, 2020
Journal
Volume
20
Issue
5
Pages
3819 - 3827
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