Role of ADAM10 as a CD30 Sheddase in Classical Hodgkin Lymphoma

Cancer cells generally recruit and influence non-malignant immune cells to support the tumor growth. Hodgkin Lymphoma (cHL) is a good example, because the affected lymphoid tissue contains only a few malignant Hodgkin- and Reed-Sternberg (H-RS) cells, which are supported by a massive infiltrate of lymphocytes, fibroblasts and innate immune cells. The transmembrane receptor CD30, which is selectively expressed on the H-RS cells, plays an...