Volumetric mapping of intra‐ and extracellular pH in the human brain using ³¹P MRSI at 7T

Purpose In vivo 31 P MRSI enables noninvasive mapping of absolute pH values via the pH‐dependent chemical shifts of inorganic phosphates (P i ). A particular challenge is the quantification of extracellular P i with low SNR in vivo. The purpose of this study was to demonstrate feasibility of assessing both intra‐ and extracellular pH across the whole human brain via volumetric 31 P MRSI at 7T. Methods 3D 31 P MRSI data sets of the brain were...