Cell death induced by cytotoxic CD8⁺T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

Background Elimination of cancer cells by some stimuli like chemotherapy and radiotherapy activates anticancer immunity after the generation of damage‐associated molecular patterns, a process recently named immunogenic cell death (ICD). Despite the recent advances in cancer immunotherapy, very little is known about the immunological consequences of cell death activated by cytotoxic CD8 + T (Tc) cells on cancer cells, that is, if Tc cells induce...