Activation of AMP‐activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness

Volume: 34, Issue: 5, Pages: 7036 - 7057
Published: Apr 4, 2020
Abstract
The purpose was to determine the role of AMPK activation in the renal metabolic response to sepsis, the development of sepsis-induced acute kidney injury (AKI) and on survival. In a prospective experimental study, 167 10- to 12-week-old C57BL/6 mice underwent cecal ligation and puncture (CLP) and human proximal tubule epithelial cells (TEC; HK2) were exposed to inflammatory mix (IM), a combination of lipopolysaccharide (LPS) and high mobility...
Paper Details
Title
Activation of AMP‐activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness
Published Date
Apr 4, 2020
Volume
34
Issue
5
Pages
7036 - 7057
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