Revisit of solubility of oxytetracycline polymorphs. An old story in the light of new results
Volume: 149, Pages: 105328 - 105328
Published: Jun 1, 2020
Abstract
In the literature the therapeutic nonequivalence of oxytetracycline hydrochloride (OTCH) capsules and tablets was attributed to the different aqueous solubility of polymorphs without their comprehensive study. Our aim was to reveal the effects of polymorphism on equilibrium solubility, dissolution kinetics and the supersaturation of two OTCH polymorphs (stable Form A and metastable Form B).The equilibrium solubility was measured in biorelevant...
Paper Details
Title
Revisit of solubility of oxytetracycline polymorphs. An old story in the light of new results
Published Date
Jun 1, 2020
Volume
149
Pages
105328 - 105328
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