Glycation Leads to Increased Polysialylation and Promotes the Metastatic Potential of Neuroblastoma Cells
Abstract
Neuroblastoma is the second most frequent extracranial tumor, affecting young children worldwide. One hallmark of tumors such as neuroblastomas, is the expression of polysialic acid, which interferes with adhesion and may promote invasion and metastasis. Since tumor cells use glycolysis for energy production, they thereby produce as side product methylglyoxal (MGO), which reacts with proteins to advanced glycation end products in a mechanism...
Paper Details
Title
Glycation Leads to Increased Polysialylation and Promotes the Metastatic Potential of Neuroblastoma Cells
Published Date
Apr 2, 2020
Journal
Volume
9
Issue
4
Pages
868 - 868
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