Molecular targeting of FATP4 transporter for oral delivery of therapeutic peptide
Abstract
Low oral bioavailability of peptide drugs has limited their application to parenteral administration, which suffers from poor patient compliance. Here, we show that molecular targeting of the FATP4 transporter is an effective approach to specifically transport long-chain fatty acid (LCFA)-conjugated peptides across the enterocytic membrane and, thus, enables oral delivery of drug peptides. We packaged LCFA-conjugated exendin-4 (LCFA-Ex4) into...
Paper Details
Title
Molecular targeting of FATP4 transporter for oral delivery of therapeutic peptide
Published Date
Apr 3, 2020
Journal
Volume
6
Issue
14
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