The solubility profile and apparent thermodynamic analysis of doxofylline in pure and mixed solvents

Crystallization and purification is an important step in drug preparation. In this work, the solubility of doxofylline in some pure and mixed solvents at T = 273.15–313.15 K was experimentally determined under 101.2 kPa. Infrared spectroscopy (IR) was used to evaluate the crystal form of doxofylline, and no solvates or new form formation were observed during the whole experiment. In pure solvent, the solubility data increased with the increasing...