THIN-LAYER CHROMATOGRAPHY ON REVERSED PHASE IN THE CHARACTERIZATION OF RETENTION BEHAVIOUR, LIPOPHILICITY, AND PHARMACOKINETICS OF CYANOACETAMIDE DERIVATIVES

Biological activity of a molecule is closely related to its lipophilicity. This significant parameter was determined for a group of potentially bioactive N-(4-phenylmonosubstituted)-2-cyanoacetamides applying thin-layer chromatography on reversed phase (RP-TLC) in mixtures of water and two organic modifiers separately, i-propanol and dioxane. The effect of the chemical structure of derivatives and the influence of the applied organic modifier on...