Polyphyllosides A–F, six new spirostanol saponins from the stems and leaves of Paris polyphylla var. chinensis

The first phytochemical investigation on the steroidal saponins from the stems and leaves of Paris polyohylla var. chinensis led to the discovery and characterization of six new spirostanol saponins, named polyphyllosides A–F (1–6), along with four known analogues (7–10). Their structures were unambiguously established via extensive spectroscopic data and chemical methods. Both polyphyllosides A and B had a rare aglycone with a C-4/C-5 double...