ADAMTS‐5: A difficult teenager turning 20
Volume: 101, Issue: 1-2, Pages: 4 - 20
Published: Feb 1, 2020
Abstract
Summary A Disintegrin And Metalloproteinase with ThromboSpondin motif (ADAMTS)‐5 was identified in 1999 as one of the enzymes responsible for cleaving aggrecan, the major proteoglycan in articular cartilage. Studies in vitro, ex vivo and in vivo have validated ADAMTS‐5 as a target in osteoarthritis (OA), a disease characterized by extensive degradation of aggrecan. For this reason, it attracted the interest of many research groups aiming to...
Paper Details
Title
ADAMTS‐5: A difficult teenager turning 20
Published Date
Feb 1, 2020
Volume
101
Issue
1-2
Pages
4 - 20
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