Critical Assessment of Targeted Protein Degradation as a Research Tool and Pharmacological Modality

Degrader molecules, small molecules that induce targeted degradation of a protein of interest, are of increasing interest in drug development and discovery. What makes degrader molecules attractive is that they offer several advantages over both small molecule inhibitors and biologics. Examples of degrader molecules that have been approved for human treatment are immunomodulatory drugs, while additional degrader molecules are undergoing clinical...