Distinct features of nucleolus-associated domains in mouse embryonic stem cells
Abstract
Heterochromatin in eukaryotic interphase cells frequently localizes to the nucleolar periphery (nucleolus-associated domains (NADs)) and the nuclear lamina (lamina-associated domains (LADs)). Gene expression in somatic cell NADs is generally low, but NADs have not been characterized in mammalian stem cells. Here, we generated the first genome-wide map of NADs in mouse embryonic stem cells (mESCs) via deep sequencing of chromatin associated with...
Paper Details
Title
Distinct features of nucleolus-associated domains in mouse embryonic stem cells
Published Date
Mar 26, 2020
Journal
Volume
129
Issue
2
Pages
121 - 139
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