The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis
Abstract
Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East Asian and European ancestries. We discover two previously unreported loci, NFKB1 (rs230540, OR = 1.25, P = 3.4 × 10−12) and IRF4 (rs9405192, OR = 1.29, P = 1.4 × 10−14), fine-map the PLA2R1 locus (rs17831251, OR = 2.25, P = 4.7 × 10−103) and report...
Paper Details
Title
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis
Published Date
Mar 30, 2020
Journal
Volume
11
Issue
1
Pages
1600 - 1618
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