Gene

Control of chromosome duplication

Replication (statistics)

Origin recognition complex

Virology

Epigenetics

Genetics

DNA replication

Chromatin

Biology

Cell biology

Eukaryotic DNA replication

Nature Cell Biology

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division. Groth and colleagues discuss recent advances in chromatin replication and maintenance across mitotic division, with emphasis on replication-coupled chromatin assembly and chromatin maturation post-replication.

Chromatin replication and epigenetic cell memory