Nanofibrous polyester-polypeptide block copolymer scaffolds with high porosity and controlled degradation promote cell adhesion, proliferation and differentiation

The nanofibrous ultrastructure of native extracellular matrix (ECM) provides topological cues for specific cellular behavior, therefore, serves as a physical template for bio-scaffolds design and fabrication. Poly(γ-benzyl- l -glutamate) (PBLG) is a commonly used polypeptide, which often self-assembles into nanofibers. However, the slow degradation of PBLG limits its application in tissue engineering. Herein, poly(D,L-lactide)-b-poly(γ-benzyl- l...