Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Abstract
Aim: To assess the potential of human induced pluripotent stem cell-derived smooth muscle cells (hiPSC-SMC) to accelerate diabetic wound healing. Methods: hiPSC-SMC were embedded in 3D collagen scaffolds and cultured in vitro for 72 h; scaffolds were then applied to diabetic, nude mouse, splinted back wounds to assess in vivo healing. Cultured medium after scaffold incubation was collected and analyzed for expression of pro-angiogenic cytokines....
Paper Details
Title
Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Published Date
Feb 1, 2020
Journal
Volume
15
Issue
2
Pages
1277 - 1293
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